REGULATION OF EDHFR-TAGGED PROTEINS WITH TRIMETHOPRIM PROTACS

Regulation of eDHFR-tagged proteins with trimethoprim PROTACs

Abstract Temporal control of protein levels in cells and living animals can be used to improve our understanding of protein function.In addition, control of engineered proteins could be used in therapeutic applications.PRoteolysis-TArgeting Chimeras (PROTACs) have emerged as a small-molecule-driven strategy to achieve rapid, post-translational regu

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The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans.

Recent findings indicate that perturbations of the mitochondrial electron transport chain (METC) can cause extended longevity in evolutionarily diverse organisms.To uncover the molecular basis of how altered METC increases lifespan in KONJAC SPONGE C.elegans, we performed an RNAi screen and revealed that three predicted transcription factors are sp

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Hazard Assessment of Debris Flow Based on Infinite Irrelevance Method and Probabilistic Neural Network Coupling Model

Debris flow is one of the most harmful natural disasters, which seriously damages the ecological environment balance, human life safety and property loss.Therefore, it is necessary to predict and assess the hazard of debris flow.This paper proposes an effective model for predicting the hazard of debris flow, which is a coupled model based on the In

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